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Article

KLF4 is a FOXO target gene that suppresses B cell proliferation

28 Mar 2008

Abstract excerpt

Lymphocytes circulate in a quiescent (G(0)) state until they encounter specific antigens. In T cells, quiescence is programmed by transcription factors of the forkhead box O (FOXO) and Krüppel-like factor (KLF) families. However, the transcription factors that regulate B cell quiescence are not known. KLF4 is a candidate tumor suppressor gene in B lymphocytes, and thus a likely candidate for regulating B cell...

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PMID: 18375530
DOI: 10.1093/intimm/dxn024

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