Krüppel‐like factor 4 (KLF4) directly regulates proliferation in thymocyte development and IL‐17 expression during Th17 differentiation

Abstract excerpt

ABSTRACT Krüppel‐like factor 4 (KLF4), a transcription factor, plays a key role in the pluripotency of stem cells. We sought to determine the function of KLF4 in T‐cell development and differentiation by using T‐cell‐specific Klf4 ‐knockout (KO) mice. We found that KLF4 was highly expressed in thymocytes and mature T cells and was rapidly down‐regulated in mature T cells after activation. In Klf4‐KO mice, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chronic Myeloid Leukemia Treatments
• Share to Genetic Syndromes and Imprinting
• Share to Kruppel-like factors research