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Article

Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells

17 Oct 2018

Abstract excerpt

Forkhead box class O1 (FOXO1) acts as a tumor suppressor in solid tumors. The oncogenic phosphoinositide-3-kinase (PI3K) pathway suppresses FOXO1 transcriptional activity by enforcing its nuclear exclusion upon AKT-mediated phosphorylation. We show here abundant nuclear expression of FOXO1 in Burkitt lymphoma (BL), a germinal center (GC) B-cell-derived lymphoma whose pathogenesis is linked to PI3K activation....

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Identifiers

PMID: 30333121
DOI: 10.1182/blood-2018-06-856203

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