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Article

Cell Cycle Genes Are the Evolutionarily Conserved Targets of the E2F4 Transcription Factor

23 Oct 2007

Abstract excerpt

Maintaining quiescent cells in G0 phase is achieved in part through the multiprotein subunit complex known as DREAM, and in human cell lines the transcription factor E2F4 directs this complex to its cell cycle targets. We found that E2F4 binds a highly overlapping set of human genes among three diverse primary tissues and an asynchronous cell line, which suggests that tissue-specific binding partners and...

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PMID: 17957245
DOI: 10.1371/journal.pone.0001061

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