Article
An N-ethyl-N-nitrosourea-induced mutation in N-acetyltransferase 1 in mice.
Biochemical and biophysical research communications - 30 May 2008
Erickson Robert P, McQueen Charlene A, Chau Binh, Gokhale Vijay, Uchiyama Masahi, Toyoda Atsushi, Ejima Fumiwo, Maho Naka, Sakaki Yoshiyuki, Gondo Yoichi
Abstract excerpt
Genetic variation in human N-acetyltransferases (NAT) has been implicated in susceptibility to aromatic amine and hydrazine carcinogens and therapeutic drugs. There are mouse models for variability of human NAT1; however mice with genetic differences in Nat1 (corresponding to human NAT2), have not been available. N-Ethyl-N-nitrosourea (ENU) mutagenesis was used to create genetic variation in Nat1. Among a number...
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