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Article

Human acetyl CoA:arylamine N-acetyltransferase variants generated by random mutagenesis.

Molecular pharmacology - 1 Jan 2004

Summerscales Joanna E, Josephy P David

Abstract excerpt

Acetyl CoA:arylamine N-acetyltransferase (NAT) enzymes catalyze the N-acetylation of aromatic amines and the O-acetylation of aryl hydroxylamines, reactions that govern the disposition and toxicity of many drugs and carcinogens. The human NAT genes and enzymes NAT1 and NAT2 are highly polymorphic and constitute one of the best studied examples of the genetic control of drug metabolism. Naturally occurring human...

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Source

Identifiers

PMID: 14722254
DOI: 10.1124/mol.65.1.220

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Human acetyl CoA:arylamine N-acetyltransferase variants generated by random mutagenesis.PMID 14722254Read ↗

Screening and characterizing human NAT2 variants.Semantic proximity Read ↗

Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2.Semantic proximity Read ↗

Human acetyltransferase polymorphisms.Semantic proximity Read ↗

Polymorphism of human acetyltransferases.Semantic proximity Read ↗

Functional genomics of C190T single nucleotide polymorphism in human N-acetyltransferase 2.Semantic proximity Read ↗

Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2.Semantic proximity Read ↗

Molecular genetics of human polymorphic N-acetyltransferase: enzymatic analysis of 15 recombinant wild-type, mutant, and chimeric NAT2 allozymes.Semantic proximity Read ↗

ArylamineN-acetyltransferasesSemantic proximity Read ↗

Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms.Semantic proximity Read ↗

Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles.Semantic proximity Read ↗

Pharmacogenetics of the arylamine N-acetyltransferases.Semantic proximity Read ↗

Computational and experimental analyses of mammalian arylamine N-acetyltransferase structure and function.Semantic proximity Read ↗

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