Article
Human acetyltransferase polymorphisms.
Mutation research - 12 May 1997
Grant D M, Hughes N C, Janezic S A, Goodfellow G H, Chen H J, Gaedigk A, Yu V L, Grewal R
Abstract excerpt
Conjugation of primary amino and hydroxylamino groups with acetate, catalyzed by acetyl CoA-dependent arylamine acetyltransferase (NAT) enzymes, may play an important role in the intricate series of metabolic pathways that produce or prevent toxicity following exposure to homo- and heterocyclic arylamine and hydrazine xenobiotics. Two independently regulated and kinetically distinct human acetyltransferases are...
Topics
- Acetylation
- Alleles
- Amines
- Aminosalicylic Acid
- Arylamine N-Acetyltransferase
- Biotransformation
- Genes
- Humans
- Isoenzymes
- Kinetics
- Polymorphism, Genetic
- Racial Groups