Article
Human acetyltransferase polymorphisms.
Mutation research - 12 May 1997
Grant D M, Hughes N C, Janezic S A, Goodfellow G H, Chen H J, Gaedigk A, Yu V L, Grewal R
Abstract excerpt
Conjugation of primary amino and hydroxylamino groups with acetate, catalyzed by acetyl CoA-dependent arylamine acetyltransferase (NAT) enzymes, may play an important role in the intricate series of metabolic pathways that produce or prevent toxicity following exposure to homo- and heterocyclic arylamine and hydrazine xenobiotics. Two independently regulated and kinetically distinct human acetyltransferases are...
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