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Article

Screening and characterizing human NAT2 variants.

Methods in enzymology - 1 Jan 2005

Savulescu Mihaela R, Mushtaq Adeel, Josephy P David

Abstract excerpt

Acetyl CoA:arylamine N-acetyltransferase (NAT; E.C. 2.3.1.5) enzymes play a key role in the metabolic activation of aromatic amine and nitroaromatic mutagens to electrophilic reactive intermediates. We have developed a system in which the activation of mutagens by recombinant human NAT2, expressed in Escherichia coli, can be detected by the appearance of Lac+ revertants. The mutagenesis assay is based on the...

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Source

Identifiers

PMID: 16399350
DOI: 10.1016/S0076-6879(05)00011-X

Genes

NAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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