Article
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
Nature genetics - 1 May 2008
Tomlinson Ian P M, Webb Emily, Carvajal-Carmona Luis, Broderick Peter, Howarth Kimberley, Pittman Alan M, Spain Sarah, Lubbe Steven, Walther Axel, Sullivan Kate, Jaeger Emma, Fielding Sarah, Rowan Andrew, Vijayakrishnan Jayaram, Domingo Enric, Chandler Ian, Kemp Zoe, Qureshi Mobshra, Farrington Susan M, Tenesa Albert, Prendergast James G D, Barnetson Rebecca A, Penegar Steven, Barclay Ella, Wood Wendy, Martin Lynn, Gorman Maggie, Thomas Huw, Peto Julian, Bishop D Timothy, Gray Richard, Maher Eamonn R, Lucassen Anneke, Kerr David, Evans D Gareth R, Schafmayer Clemens, Buch Stephan, Völzke Henry, Hampe Jochen, Schreiber Stefan, John Ulrich, Koessler Thibaud, Pharoah Paul, van Wezel Tom, Morreau Hans, Wijnen Juul T, Hopper John L, Southey Melissa C, Giles Graham G, Severi Gianluca, Castellví-Bel Sergi, Ruiz-Ponte Clara, Carracedo Angel, Castells Antoni, Försti Asta, Hemminki Kari, Vodicka Pavel, Naccarati Alessio, Lipton Lara, Ho Judy W C, Cheng K K, Sham Pak C, Luk J, Agúndez Jose A G, Ladero Jose M, de la Hoya Miguel, Caldés Trinidad, Niittymäki Iina, Tuupanen Sari, Karhu Auli, Aaltonen Lauri, Cazier Jean-Baptiste, Campbell Harry, Dunlop Malcolm G, Houlston Richard S
Abstract excerpt
To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10(-4) in a joint analysis of...
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