Article
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
Nature genetics - 1 Nov 2010
Houlston Richard S, Cheadle Jeremy, Dobbins Sara E, Tenesa Albert, Jones Angela M, Howarth Kimberley, Spain Sarah L, Broderick Peter, Domingo Enric, Farrington Susan, Prendergast James G D, Pittman Alan M, Theodoratou Evi, Smith Christopher G, Olver Bianca, Walther Axel, Barnetson Rebecca A, Churchman Michael, Jaeger Emma E M, Penegar Steven, Barclay Ella, Martin Lynn, Gorman Maggie, Mager Rachel, Johnstone Elaine, Midgley Rachel, Niittymäki Iina, Tuupanen Sari, Colley James, Idziaszczyk Shelley, Thomas Huw J W, Lucassen Anneke M, Evans D Gareth R, Maher Eamonn R, Maughan Timothy, Dimas Antigone, Dermitzakis Emmanouil, Cazier Jean-Baptiste, Aaltonen Lauri A, Pharoah Paul, Kerr David J, Carvajal-Carmona Luis G, Campbell Harry, Dunlop Malcolm G, Tomlinson Ian P M
Abstract excerpt
Genome-wide association studies (GWAS) have identified ten loci harboring common variants that influence risk of developing colorectal cancer (CRC). To enhance the power to identify additional CRC risk loci, we conducted a meta-analysis of three GWAS from the UK which included a total of 3,334 affected individuals (cases) and 4,628 controls followed by multiple validation analyses including a total of 18,095...
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