Article
Susceptibility genetic variants associated with early-onset colorectal cancer.
Carcinogenesis - 1 Mar 2012
Giráldez María Dolores, López-Dóriga Adriana, Bujanda Luis, Abulí Anna, Bessa Xavier, Fernández-Rozadilla Ceres, Muñoz Jenifer, Cuatrecasas Miriam, Jover Rodrigo, Xicola Rosa M, Llor Xavier, Piqué Josep M, Carracedo Angel, Ruiz-Ponte Clara, Cosme Angel, Enríquez-Navascués José María, Moreno Victor, Andreu Montserrat, Castells Antoni, Balaguer Francesc, Castellví-Bel Sergi
Abstract excerpt
Colorectal cancer (CRC) is the second most common cancer in Western countries. Hereditary forms only correspond to 5% of CRC burden. Recently, genome-wide association studies have identified common low-penetrant CRC genetic susceptibility loci. Early-onset CRC (CRC<50 years old) is especially suggestive of hereditary predisposition although 85-90% of heritability still remains unidentified. CRC<50 patients (n =...
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