Article
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.
Nature genetics - 1 Aug 2007
Tomlinson Ian, Webb Emily, Carvajal-Carmona Luis, Broderick Peter, Kemp Zoe, Spain Sarah, Penegar Steven, Chandler Ian, Gorman Maggie, Wood Wendy, Barclay Ella, Lubbe Steven, Martin Lynn, Sellick Gabrielle, Jaeger Emma, Hubner Richard, Wild Ruth, Rowan Andrew, Fielding Sarah, Howarth Kimberley, Silver Andrew, Atkin Wendy, Muir Kenneth, Logan Richard, Kerr David, Johnstone Elaine, Sieber Oliver, Gray Richard, Thomas Huw, Peto Julian, Cazier Jean-Baptiste, Houlston Richard
Abstract excerpt
Much of the variation in inherited risk of colorectal cancer (CRC) is probably due to combinations of common low risk variants. We conducted a genome-wide association study of 550,000 tag SNPs in 930 familial colorectal tumor cases and 960 controls. The most strongly associated SNP (P = 1.72 x 10(-7), allelic test) was rs6983267 at 8q24.21. To validate this finding, we genotyped rs6983267 in three additional CRC...
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