Article
Genome-wide association study identifies two new susceptibility loci for colorectal cancer at 5q23.3 and 17q12 in Han Chinese.
Oncotarget - 24 Nov 2015
Jiang Kewei, Sun Yimin, Wang Cheng, Ji Jiafu, Li Yaoping, Ye Yingjiang, Lv Liang, Guo Yong, Guo Sutang, Li Hai, Zhang Lianhai, Zhou Yanbing, Jiang Bo, Ren Yonghong, Xu Youchun, Yang Xiongfei, Liu Hongxia, Wang Yirui, Shen Zhanlong, Qin Wenyan, Guo Peng, Jiang Yuyang, Hu Zhibin, Shen Hongbing, Cheng Jing, Yang Yinxue, Wang Shan
Abstract excerpt
Genome-wide association studies (GWAS) have reported a number of loci harboring common variants that influence risk of colorectal cancer (CRC) in European descent. But all the SNPs identified explained a small fraction of total heritability. To identify more genetic factors that modify the risk of CRC, especially Chinese Han specific, we conducted a three-stage GWAS including a screening stage (932 CRC cases and...
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