Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

doi:10.1053/j.gastro.2016.02.076

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Article

Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

Gastroenterology - 1 Jun 2016

Zeng Chenjie, Matsuda Koichi, Jia Wei-Hua, Chang Jiang, Kweon Sun-Seog, Xiang Yong-Bing, Shin Aesun, Jee Sun Ha, Kim Dong-Hyun, Zhang Ben, Cai Qiuyin, Guo Xingyi, Long Jirong, Wang Nan, Courtney Regina, Pan Zhi-Zhong, Wu Chen, Takahashi Atsushi, Shin Min-Ho, Matsuo Keitaro, Matsuda Fumihiko, Gao Yu-Tang, Oh Jae Hwan, Kim Soriul, Jung Keum Ji, Ahn Yoon-Ok, Ren Zefang, Li Hong-Lan, Wu Jie, Shi Jiajun, Wen Wanqing, Yang Gong, Li Bingshan, Ji Bu-Tian, Brenner Hermann, Schoen Robert E, Küry Sébastien, Gruber Stephen B, Schumacher Fredrick R, Stenzel Stephanie L, Casey Graham, Hopper John L, Jenkins Mark A, Kim Hyeong-Rok, Jeong Jin-Young, Park Ji Won, Tajima Kazuo, Cho Sang-Hee, Kubo Michiaki, Shu Xiao-Ou, Lin Dongxin, Zeng Yi-Xin, Zheng Wei

Abstract excerpt

BACKGROUND & AIMS: Known genetic factors explain only a small fraction of genetic variation in colorectal cancer (CRC). We conducted a genome-wide association study to identify risk loci for CRC. METHODS: This discovery stage included 8027 cases and 22,577 controls of East-Asian ancestry. Promising variants were evaluated in studies including as many as 11,044 cases and 12,047 controls. Tumor-adjacent normal...

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PMID: 26965516
DOI: 10.1053/j.gastro.2016.02.076
PMCID: PMC4909543

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