Article
Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer.
Human molecular genetics - 1 Dec 2008
Pittman Alan M, Webb Emily, Carvajal-Carmona Luis, Howarth Kimberley, Di Bernardo Maria Chiara, Broderick Peter, Spain Sarah, Walther Axel, Price Amy, Sullivan Kate, Twiss Philip, Fielding Sarah, Rowan Andrew, Jaeger Emma, Vijayakrishnan Jayaram, Chandler Ian, Penegar Steven, Qureshi Mobshra, Lubbe Steven, Domingo Enric, Kemp Zoe, Barclay Ella, Wood Wendy, Martin Lynn, Gorman Maggie, Thomas Huw, Peto Julian, Bishop Timothy, Gray Richard, Maher Eamonn R, Lucassen Anneke, Kerr David, Evans Gareth R, van Wezel Tom, Morreau Hans, Wijnen Juul T, Hopper John L, Southey Melissa C, Giles Graham G, Severi Gianluca, Castellví-Bel Sergi, Ruiz-Ponte Clara, Carracedo Angel, Castells Antoni, Försti Asta, Hemminki Kari, Vodicka Pavel, Naccarati Alessio, Lipton Lara, Ho Judy W C, Cheng K K, Sham Pak C, Luk J, Agúndez Jose A G, Ladero Jose M, de la Hoya Miguel, Caldés Trinidad, Niittymäki Iina, Tuupanen Sari, Karhu Auli, Aaltonen Lauri A, Cazier Jean-Baptiste, Tomlinson Ian P M, Houlston Richard S
Abstract excerpt
The common single-nucleotide polymorphism (SNP) rs3802842 at 11q23.1 has recently been reported to be associated with risk of colorectal cancer (CRC). To examine this association in detail we genotyped rs3802842 in eight independent case-control series comprising a total of 10 638 cases and 10 457 healthy individuals. A significant association between the C allele of and CRC risk was found (per allele...