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Article

Clathrin Heavy Chain Gene Fusions Expressed in Human Cancers: Analysis of Cellular Functions

2 Mar 2011

Abstract excerpt

Clathrin is a protein expressed ubiquitously that has important functions in membrane trafficking and mitosis. Two different gene fusions involving clathrin heavy chain (CHC) have been described in human cancers. These involve either anaplastic lymphoma kinase (ALK) or transcription factor binding to IGHM enhancer 3 (TFE3) and raise the possibility that altered clathrin function in cells expressing the fusion...

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PMID: 21362119
DOI: 10.1111/j.1600-0854.2011.01183.x

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