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Article

The cytoplasmic side of p53's oncosuppressive activities

18 Apr 2014

Abstract excerpt

The tumor suppressor p53 is a transcription factor that in response to a plethora of stress stimuli activates a complex and context-dependent cellular response ultimately protecting genome integrity. In the last two decades, the discovery of cytoplasmic p53 localization has driven an intense research on its extra-nuclear functions. The ability to induce apoptosis acting directly at mitochondria and the related...

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PMID: 24747877
DOI: 10.1016/j.febslet.2014.04.015

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