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Article

Disruption of clathrin-mediated trafficking causes centrosome overduplication and senescence.

Traffic (Copenhagen, Denmark) - 1 Jan 2014

Olszewski Maciej B, Chandris Panagiotis, Park Bum-Chan, Eisenberg Evan, Greene Lois E

Abstract excerpt

The Hsc70 cochaperone, G cyclin-associated kinase (GAK), has been shown to be essential for the chaperoning of clathrin by Hsc70 in the cell. In this study, we used conditional GAK knockout mouse embryonic fibroblasts (MEFs) to determine the effect of completely inhibiting clathrin-dependent trafficking on the cell cycle. After GAK was knocked out, the cells developed the unusual phenotype of having multiple...

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Identifiers

PMID: 24138026
DOI: 10.1111/tra.12132
PMCID: PMC3868896

Genes

GAK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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