Hedgehog signaling and the glioma-associated oncogene in cancer radioresistance

doi:10.3389/fcell.2023.1257173

Article

Hedgehog signaling and the glioma-associated oncogene in cancer radioresistance

13 Nov 2023

Abstract excerpt

Tumor radioresistance remains a key clinical challenge. The Hedgehog (HH) signaling pathway and glioma-associated oncogene (GLI) are aberrantly activated in several cancers and are thought to contribute to cancer radioresistance by influencing DNA repair, reactive oxygen species production, apoptosis, autophagy, cancer stem cells, the cell cycle, and the tumor microenvironment. GLI is reported to activate the...

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