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The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human Cancer

21 Jul 2015

Abstract excerpt

Defined cellular mechanisms have evolved that recognize and repair DNA to protect the integrity of its structure and sequence when encountering assaults from endogenous and exogenous sources. There are five major DNA repair pathways: mismatch repair, nucleotide excision repair, direct repair, base excision repair and DNA double strand break repair (including non-homologous end joining and homologous recombination...

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PMID: 26197339
DOI: 10.3390/cancers7030839

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