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Article

Hedgehog signaling pathway as a therapeutic target in various types of cancer.

Cancer science - 1 Oct 2011

Onishi Hideya, Katano Mitsuo

Abstract excerpt

Hedgehog (Hh) signaling is an important factor in growth and patterning during embryonic development. A mutation in Patched, Smoothened or Gli1, which regulate the Hh signaling pathway, might lead to the onset of glioblastoma, basal cell carcinoma, medulloblastoma and rhabdomyosarcoma. Recently, Hh signaling has been reported to be activated in a ligand-dependent manner, contributing to carcinogenesis and cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21679342
DOI: 10.1111/j.1349-7006.2011.02010.x

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