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Article

The Utility of Hedgehog Signaling Pathway Inhibition for Cancer

31 Jul 2012

Abstract excerpt

The Hedgehog (Hh) signaling pathway has been implicated in tumor initiation and metastasis across different malignancies. Major mechanisms by which the Hh pathway is aberrantly activated can be attributed to mutations of members of Hh pathway or excessive/inappropriate expression of Hh pathway ligands. The Hh signaling pathway also affects the regulation of cancer stem cells, leading to their capabilities in...

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PMID: 22851551
DOI: 10.1634/theoncologist.2011-0450

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