Article
CpG island methylator phenotype involving tumor suppressor genes located on chromosome 3p in non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 Oct 2008
Liu Zeyi, Zhao Jun, Chen Xiao-Feng, Li Wenwen, Liu Rengyun, Lei Zhe, Liu Xia, Peng Xiaobei, Xu Ke, Chen Jun, Liu Hongyu, Zhou Qing-Hua, Zhang Hong-Tao
Abstract excerpt
CpG island methylator phenotype (CIMP) involving methylation abnormalities of tumor suppressor gene (TSG) on short arm of chromosome 3 (chromosome 3p) has not been so far epigenetically elucidated in non-small cell lung cancer (NSCLC). Using methylation-specific PCR (MSP) method, we examined methylation profiles for eight TSGs harbored in chromosome 3p in 60 NSCLC tissues and 60 paired normal tissues as well as...
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