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The two single nucleotide polymorphisms in the H37/RBM5 tumour suppressor gene at 3p21.3 correlated with different subtypes of non-small cell lung cancers.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2007

Oh Juliana J, Koegel Ashley K, Phan Diana T, Razfar Ali, Slamon Dennis J

Abstract excerpt

Allele loss and genetic alteration in chromosome 3p, particularly in 3p21.3 region, are the most frequent and the earliest genomic abnormalities found in lung cancer. Multiple 3p21.3 genes exhibit various degrees of tumour suppression activity suggesting that 3p21.3 genes may function as an integrated tumour suppressor region through their diverse biological activities. We have previously demonstrated growth...

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Identifiers

PMID: 17606309
DOI: 10.1016/j.lungcan.2007.05.020
PMCID: PMC2071930

Genes

RBM5

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