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Article

Association between the CpG island methylator phenotype and its prognostic significance in primary pulmonary adenocarcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Aug 2016

Koh Young Wha, Chun Sung-Min, Park Young-Soo, Song Joon Seon, Lee Geon Kook, Khang Shin Kwang, Jang Se Jin

Abstract excerpt

Aberrant methylation of promoter CpG islands is one of the most important inactivation mechanisms for tumor suppressor and tumor-related genes. Previous studies using genome-wide DNA methylation microarray analysis have suggested the existence of a CpG island methylator phenotype (CIMP) in lung adenocarcinomas. Although the biological behavior of these tumors varies according to tumor stage, no large-scale study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26867769
DOI: 10.1007/s13277-016-4932-2

Genes

ACAN
CCNA1
EDARADD
EGFR
GFRA1

Provenance

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