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Article

Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2002

Tomizawa Yoshio, Kohno Takashi, Kondo Haruhiko, Otsuka Ayaka, Nishioka Michiho, Niki Toshiro, Yamada Tesshi, Maeshima Arafumi, Yoshimura Kimio, Saito Ryusei, Minna John D, Yokota Jun

Abstract excerpt

PURPOSE: Chromosome 3p is deleted frequently in various types of human cancers, including lung cancer. Recently, the RASSF1A gene was isolated from the 3p21.3 region homozygously deleted in lung and breast cancer cell lines, and it was shown to be inactivated by hypermethylation of the promoter region in lung cancers. In this study, we investigated the pathogenetic and clinicopathological significances of RASSF1A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12114441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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