Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer.

Cancer - 15 May 2006

Suzuki Makoto, Shigematsu Hisayuki, Iizasa Toshihiko, Hiroshima Kenzo, Nakatani Yukio, Minna John D, Gazdar Adi F, Fujisawa Takehiko

Abstract excerpt

BACKGROUND: Both genetic and epigenetic changes in nonsmall cell lung cancer (NSCLC) are known to be a common event. METHODS: Mutations in the epidermal growth factor receptor gene (EGFR), HER-2, and KRAS and the methylation profile of 9 genes for NSCLC were analyzed and correlated with clinical and histologic data. RESULTS: Thirty-nine EGFR, 4 HER-2, and 6 KRAS mutations were found in 150 NSCLC cases, with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy, Needle
Share to Genes, erbB-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, erbB-2

Share to Genes, ras

Share to Multivariate Analysis

Share to Probability

Share to Proportional Hazards Models

Share to Survival Analysis

Source

Identifiers

PMID: 16598760
DOI: 10.1002/cncr.21853

Genes

EGFR
KRAS
SPARC
CDH13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer.PMID 16598760Read ↗

CHFR hypermethylation and EGFR mutation are mutually exclusive and exhibit contrastive clinical backgrounds and outcomes in non-small cell lung cancer.Semantic proximity Read ↗

Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers.Semantic proximity Read ↗

Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC)Semantic proximity Read ↗

Molecular characterization of chronic obstructive pulmonary disease-related non-small cell lung cancer through aberrant methylation and alterations of EGFR signaling.Semantic proximity Read ↗

CpG island methylator phenotype involving tumor suppressor genes located on chromosome 3p in non-small cell lung cancer.Semantic proximity Read ↗

Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers.Semantic proximity Read ↗

Aberrant Promoter Methylation Profile and Association with Survival in Patients with Non–Small Cell Lung CancerSemantic proximity Read ↗

Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non small cell lung cancer.Semantic proximity Read ↗

Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: relation with smoking status.Semantic proximity Read ↗

CHFR aberrant methylation involves a subset of human lung adenocarcinoma associated with poor clinical outcomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.