Article
Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas.
Cancer letters - 18 Mar 2007
Abe Masanobu, Westermann Frank, Nakagawara Akira, Takato Tsuyoshi, Schwab Manfred, Ushijima Toshikazu
Abstract excerpt
The CpG island methylator phenotype (CIMP) was closely associated with poor overall survival (OS) in Japanese neuroblastoma (NBL) cases in our previous study. Here, in German NBL cases, CIMP(+) cases (n=95) showed markedly poorer OS (hazard ratio (HR)=9.5; P<0.0001) and disease-free survival (DFS...
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