Article
CpG island methylator phenotype involving chromosome 3p confers an increased risk of non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jun 2010
Liu Zeyi, Li Wenwen, Lei Zhe, Zhao Jun, Chen Xiao-Feng, Liu Rengyun, Peng Xiaobei, Wu Zhi-hao, Chen Jun, Liu Hongyu, Zhou Qing-Hua, Zhang Hong-Tao
Abstract excerpt
PURPOSE: This study aims to explore the association of CpG island methylator phenotype (CIMP) involving tumor suppressor genes on short arm of chromosome 3 (3p) with increased risk of non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: In this study, four NSCLC cell lines were cultured, and peripheral blood mononuclear cell (PBMC) specimens from 80 patients with NSCLC and 80 matched controls were collected...
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