Article
A systematic study of gene mutations in urothelial carcinoma; inactivating mutations in TSC2 and PIK3R1.
PloS one - 14 Apr 2011
Sjödahl Gottfrid, Lauss Martin, Gudjonsson Sigurdur, Liedberg Fredrik, Halldén Christer, Chebil Gunilla, Månsson Wiking, Höglund Mattias, Lindgren David
Abstract excerpt
BACKGROUND: Urothelial carcinoma (UC) is characterized by frequent gene mutations of which activating mutations in FGFR3 are the most frequent. Several downstream targets of FGFR3 are also mutated in UC, e.g., PIK3CA, AKT1, and RAS. Most mutation studies of UCs have been focused on single or a few genes at the time or been performed on small sample series. This has limited the possibility to investigate...
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