Article
Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern.
Proceedings of the National Academy of Sciences of the United States of America - 14 Aug 2007
Hafner Christian, López-Knowles Elena, Luis Nuno M, Toll Agustí, Baselga Eulàlia, Fernández-Casado Alex, Hernández Silvia, Ribé Adriana, Mentzel Thomas, Stoehr Robert, Hofstaedter Ferdinand, Landthaler Michael, Vogt Thomas, Pujol Ramòn M, Hartmann Arndt, Real Francisco X
Abstract excerpt
Activating mutations of the p110 alpha subunit of PI3K (PIK3CA) oncogene have been identified in a broad spectrum of malignant tumors. However, their role in benign or preneoplastic conditions is unknown. Activating FGF receptor 3 (FGFR3) mutations are common in benign skin lesions, either as embryonic mutations in epidermal nevi (EN) or as somatic mutations in seborrheic keratoses (SK). FGFR3 mutations are also...
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