Activation of RAS family genes in urothelial carcinoma.

doi:10.1016/j.juro.2009.01.011

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Article

Activation of RAS family genes in urothelial carcinoma.

The Journal of urology - 1 May 2009

Boulalas I, Zaravinos A, Karyotis I, Delakas D, Spandidos D A

Abstract excerpt

PURPOSE: Bladder cancer is the fifth most common malignancy in men in Western society. We determined RAS codon 12 and 13 point mutations and evaluated mRNA expression levels in transitional cell carcinoma cases. MATERIALS AND METHODS: Samples from 30 human bladder cancers and 30 normal tissues were analyzed by polymerase chain reaction/restriction fragment length polymorphism and direct sequencing to determine...

Topics

Adult
Aged
Aged, 80 and over
Biopsy, Needle
Carcinoma, Transitional Cell
Case-Control Studies
Codon
DNA Mutational Analysis
DNA, Neoplasm
Female
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, ras

Genetic Predisposition to Disease

Humans

Immunohistochemistry

Male

Middle Aged

Multivariate Analysis

Source

Open in PubMed

Identifiers

PMID: 19303097
DOI: 10.1016/j.juro.2009.01.011

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