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Article

TP53 and PIK3CA gene mutations in adenocarcinoma, squamous cell carcinoma and high-grade intraepithelial neoplasia of the cervix.

Journal of translational medicine - 16 Sept 2014

Tornesello Maria Lina, Annunziata Clorinda, Buonaguro Luigi, Losito Simona, Greggi Stefano, Buonaguro Franco M

Abstract excerpt

BACKGROUND: Mutations in the tumor suppressor gene TP53 and proto-oncogene PIK3CA and alterations of p53 and PIK3CA AKT mTOR pathways are common events in several human cancers. We focused on the analysis of TP53 and PIK3CA gene variations in adenocarcinoma, squamous cell carcinoma as well as in intraepithelial neoplasia grade 3 of the cervix. METHODS: DNA samples from 28 cervical adenocarcinoma, 55 squamous cell...

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Identifiers

PMID: 25220666
DOI: 10.1186/s12967-014-0255-5
PMCID: PMC4174264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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