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Article

PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors.

Cancer research - 1 Aug 2006

López-Knowles Elena, Hernández Silvia, Malats Núria, Kogevinas Manolis, Lloreta Josep, Carrato Alfredo, Tardón Adonina, Serra Consol, Real Francisco X

Abstract excerpt

Bladder tumors constitute a very heterogeneous disease. Superficial tumors are characterized by a high prevalence of FGFR3 mutations and chromosome 9 alterations. High-grade and muscle-invasive tumors are characterized by Tp53 mutations and aneuploidy. We have analyzed the sequence of exons 9 and 20 of PIK3CA in a panel of bladder tumors covering the whole spectrum of the disease. DNA from formalin-fixed,...

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Source

Identifiers

PMID: 16885334
DOI: 10.1158/0008-5472.CAN-06-1182

Genes

FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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