New methods for the detection of genetic variation.

Article

New methods for the detection of genetic variation.

Annali dell'Istituto superiore di sanita - 1 Jan 1991

Vijg J

Abstract excerpt

The possibility to detect variations in the genetic material is limiting to measure DNA sequence variations occurring at low frequency, such as somatic mutations responsible for the generation of diversity in the immunoglobulin genes. In order to study mutations, a system has been developed using...

Topics

Animals
Bacteriophage lambda
DNA Fingerprinting
DNA Mutational Analysis
Genetic Variation
Genetic Vectors
Mice
Mice, Transgenic
Mutagenicity Tests
Mutation
Selection, Genetic

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