Article
Somatic mutations and cellular aging: two-dimensional DNA typing of rat fibroblast clones.
Mutation research - 1 Jan 2000
Slagboom P E, Mullaart E, Droog S, Vijg J
Abstract excerpt
Aging may be explained, to some extent, as a stochastic process of macromolecular damage. The rate of such a process should then determine longevity and be genetically controlled, as can be derived from the species specificity of maximum lifespan. The genome of the somatic cell is a major candidate to study for loss of DNA sequence integrity during aging. Unfortunately, a lack of adequate techniques has thus far...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Cells, Cultured
- Cellular Senescence
- DNA
- Female
- Fibroblasts
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Rats