Article
Unexpected behavior of H2Kb mutant DNAs in denaturing gradient gel electrophoresis.
Nucleic acids research - 25 Jun 1991
Weber C K, Shaffer D J, Sidman C L
Abstract excerpt
Denaturing gradient gel electrophoresis (DGGE) is based upon the different melting behaviors of DNA molecules in a chemical denaturant gradient according to their sequences. This technique has recently become a widespread tool to detect mutations. The introduction of a GC-clamp enables the detect...
Topics
- Animals
- Base Sequence
- DNA
- Electrophoresis, Polyacrylamide Gel
- Haplotypes
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Nucleic Acid Denaturation
- Polymerase Chain Reaction