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Article

Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells.

Molecular biology of the cell - 1 Jun 2008

Katsuno Tatsuya, Umeda Kazuaki, Matsui Takeshi, Hata Masaki, Tamura Atsushi, Itoh Masahiko, Takeuchi Kosei, Fujimori Toshihiko, Nabeshima Yo-ichi, Noda Tetsuo, Tsukita Shoichiro, Tsukita Sachiko

Abstract excerpt

Zonula occludens (ZO)-1/2/3 are the members of the TJ-MAGUK family of membrane-associated guanylate kinases associated with tight junctions. To investigate the role of ZO-1 (encoded by Tjp1) in vivo, ZO-1 knockout (Tjp1(-/-)) mice were generated by gene targeting. Although heterozygous mice showed normal development and fertility, delayed growth and development were evident from E8.5 onward in Tjp1(-/-) embryos,...

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Identifiers

PMID: 18353970
DOI: 10.1091/mbc.e07-12-1215
PMCID: PMC2397322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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