Article
Complex phenotype of mice lacking occludin, a component of tight junction strands.
Molecular biology of the cell - 1 Dec 2000
Saitou M, Furuse M, Sasaki H, Schulzke J D, Fromm M, Takano H, Noda T, Tsukita S
Abstract excerpt
Occludin is an integral membrane protein with four transmembrane domains that is exclusively localized at tight junction (TJ) strands. Here, we describe the generation and analysis of mice carrying a null mutation in the occludin gene. Occludin -/- mice were born with no gross phenotype in the expected Mendelian ratios, but they showed significant postnatal growth retardation. Occludin -/- males produced no...
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