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Article

Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2008

Tanjore Harikrishna, Zeisberg Elisabeth M, Gerami-Naini Behzad, Kalluri Raghu

Abstract excerpt

Integrins are a family of cell adhesion receptors that are involved in cell-matrix and cell-cell communications. They facilitate cell proliferation, migration, and survival. Using the Cre-Lox system, we deleted beta1 integrin on Tie2-positive (Tie2-cre beta1 Int (fl/fl)) vascular endothelial cells. Deletion of beta1 integrin on vascular endothelial cells results in embryonic lethality. Blood vessel defects are...

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Share to Endothelial Cells
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Integrin beta1

Share to Mice, Transgenic

Share to Neovascularization, Physiologic

Share to Platelet Endothelial Cell Adhesion Molecule-1

Share to Receptor, TIE-2

Source

Identifiers

PMID: 18058911
DOI: 10.1002/dvdy.21385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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