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Article

Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65.

Molecular and cellular biology - 1 Jan 2006

Morin-Kensicki Elizabeth M, Boone Brian N, Howell Michael, Stonebraker Jaclyn R, Teed Jeremy, Alb James G, Magnuson Terry R, O'Neal Wanda, Milgram Sharon L

Abstract excerpt

YAP is a multifunctional adapter protein and transcriptional coactivator with several binding partners well described in vitro and in cell culture. To explore in vivo requirements for YAP, we generated mice carrying a targeted disruption of the Yap gene. Homozygosity for the Yap(tm1Smil) allele (Yap-/-) caused developmental arrest around E8.5. Phenotypic characterization revealed a requirement for YAP in yolk sac...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neovascularization, Physiologic

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Source

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Identifiers

PMID: 16354681
DOI: 10.1128/MCB.26.1.77-87.2006
PMCID: PMC1317614

Genes

PECAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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