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Article

A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development.

Molecular and cellular biology - 1 Mar 2003

Takahashi Takamune, Takahashi Keiko, St John Patricia L, Fleming Paul A, Tomemori Takuya, Watanabe Toshio, Abrahamson Dale R, Drake Christopher J, Shirasawa Takuji, Daniel Thomas O

Abstract excerpt

Vascularization defects in genetic recombinant mice have defined critical roles for a number of specific receptor tyrosine kinases. Here we evaluated whether an endothelium-expressed receptor tyrosine phosphatase, CD148 (DEP-1/PTPeta), participates in developmental vascularization. A mutant allele, CD148(DeltaCyGFP), was constructed to eliminate CD148 phosphatase activity by in-frame replacement of cytoplasmic...

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Identifiers

PMID: 12588999
DOI: 10.1128/MCB.23.5.1817-1831.2003
PMCID: PMC151692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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