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Article

Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity.

Basic & clinical pharmacology & toxicology - 1 Jul 2008

Qian Su, Mumick Sheena, Nizner Peter, Tota Michael R, Menetski Joseph, Reitman Marc L, Macneil Douglas J

Abstract excerpt

Cytosolic malic enzyme (ME-1) is a nicotinamide adenine dinucleotide phosphate (NADP)-dependent enzyme that generates NADPH. The activity of this enzyme, the reversible oxidative decarboxylation of malate to yield pyruvate, links glycolytic pathway to citric acid cycle. The high level of ME-1 expression in liver, and its involvement in NADPH production, suggests reduced ME-1 activity might compromise hepatic...

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Identifiers

PMID: 18346052
DOI: 10.1111/j.1742-7843.2008.00228.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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