Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues.

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Article

Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues.

Cancer research - 15 Dec 1990

Spencer S R, Wilczak C A, Talalay P

Abstract excerpt

Dimethyl fumarate and dimethyl maleate are potent inducers of cytosolic NAD(P)H:(quinone acceptor) oxidoreductase (here designated quinone reductase) activity in Hepa 1c1c7 murine hepatoma cells in culture, whereas fumaric and maleic acids are much less potent, in agreement with the much greater...

Topics

Animals
Cell Line
Cytosol
Enzyme Induction
Female
Fumarates
Ligands
Liver
Liver Neoplasms, Experimental
Mice
Mutation
NAD(P)H Dehydrogenase (Quinone)
Organ Specificity
Quinone Reductases
Rats
Rats, Inbred Strains
Species Specificity
Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 2123743

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2123743-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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