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Article

Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency.

Biological chemistry - 1 Nov 2005

Meyer Ralf P, Lindberg Raija L P, Hoffmann Francine, Meyer Urs A

Abstract excerpt

Previous work has demonstrated that the function of extrahepatic cytochrome P450 CYP1A1 is dependent on the availability of heme. CYP1A1 is involved in the activation of polyaromatic hydrocarbons. In the present study we used a transgenic mouse model with chronic impairment of heme synthesis - female porphobilinogen deaminase-deficient (PBGD-/-) mice - to investigate the effects of limited heme in untreated and...

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Identifiers

PMID: 16307481
DOI: 10.1515/BC.2005.132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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