Article
Characterization of phenotypes in Gstm1-null mice by cytosolic and in vivo metabolic studies using 1,2-dichloro-4-nitrobenzene.
Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2006
Fujimoto Kazunori, Arakawa Shingo, Shibaya Yukari, Miida Hiroaki, Ando Yosuke, Yasumo Hiroaki, Hara Ayako, Uchiyama Minoru, Iwabuchi Haruo, Takasaki Wataru, Manabe Sunao, Yamoto Takashi
Abstract excerpt
Glutathione S-transferase Mu 1 (GSTM1) has been regarded as one of the key enzymes involved in phase II reactions in the liver, because of its high expression level. In this study, we generated mice with disrupted glutathione S-transferase Mu 1 gene (Gstm1-null mice) by gene targeting, and characterized the phenotypes by cytosolic and in vivo studies. The resulting Gstm1-null mice appeared to be normal and were...
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