Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulating GSH synthesis using glutamate cysteine ligase transgenic and gene-targeted mice.

Drug metabolism reviews - 1 Jan 2008

Botta Dianne, White Collin C, Vliet-Gregg Portia, Mohar Isaac, Shi Shengli, McGrath Monica B, McConnachie Lisa A, Kavanagh Terrance J

Abstract excerpt

Glutathione (GSH) is an important antioxidant and cofactor for glutathione S-transferase conjugation. GSH synthesis is catalyzed by glutamate cysteine ligase (GCL), composed of catalytic (GCLC) and modifier (GCLM) subunits. Transgenic mice that conditionally over express GCL subunits are protected from acetaminophen induced liver injury. Gclm null mice exhibit low GSH levels and enhanced sensitivity to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetaminophen
Share to Antioxidants

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Glutamate-Cysteine Ligase

Share to Glutathione

Share to Liver Diseases

Share to Mice, Transgenic

Source

Identifiers

PMID: 18642143
DOI: 10.1080/03602530802186587

Genes

GCLC
GCLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulating GSH synthesis using glutamate cysteine ligase transgenic and gene-targeted mice.PMID 18642143Read ↗

Glutamate cysteine ligase (GCL) transgenic and gene-targeted mice for controlling glutathione synthesis.Semantic proximity Read ↗

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response.Semantic proximity Read ↗

Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous.Semantic proximity Read ↗

Compromised glutathione synthesis results in high susceptibility to acetaminophen hepatotoxicity in acatalasemic mice.Semantic proximity Read ↗

Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice.Semantic proximity Read ↗

Genetically altered mice to evaluate glutathione homeostasis in health and disease.Semantic proximity Read ↗

Manipulation of cellular GSH biosynthetic capacity via TAT-mediated protein transduction of wild-type or a dominant-negative mutant of glutamate cysteine ligase alters cell sensitivity to oxidant-induced cytotoxicity.Semantic proximity Read ↗

Deletion of Glyoxalase 1 exacerbates acetaminophen-induced hepatotoxicity in miceSemantic proximity Read ↗

Enzymatic defects underlying hereditary glutamate cysteine ligase deficiency are mitigated by association of the catalytic and regulatory subunits.Semantic proximity Read ↗

Prevention of age-related truncation of γ-glutamylcysteine ligase catalytic subunit (GCLC) delays cataract formation.Semantic proximity Read ↗

Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice.Semantic proximity Read ↗

Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.