Article
Modification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions.
The Journal of biological chemistry - 25 Jul 2008
Mauri Federico, McNamee Laura M, Lunardi Andrea, Chiacchiera Fulvio, Del Sal Giannino, Brodsky Michael H, Collavin Licio
Abstract excerpt
Conjugation to SUMO is a reversible post-translational modification that regulates several transcription factors involved in cell proliferation, differentiation, and disease. The p53 tumor suppressor can be modified by SUMO-1 in mammalian cells, but the functional consequences of this modification are unclear. Here, we demonstrate that the Drosophila homolog of human p53 can be efficiently sumoylated in insect...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.