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Article

SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor.

Science signaling - 9 Feb 2010

Sehat Bita, Tofigh Ali, Lin Yingbo, Trocmé Eric, Liljedahl Ulrika, Lagergren Jens, Larsson Olle

Abstract excerpt

The insulin-like growth factor 1 receptor (IGF-1R) plays crucial roles in developmental and cancer biology. Most of its biological effects have been ascribed to its tyrosine kinase activity, which propagates signaling through the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. Here, we report that IGF-1 promotes the modification of IGF-1R by small ubiquitin-like modifier protein-1...

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Identifiers

PMID: 20145208
DOI: 10.1126/scisignal.2000628

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