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Article

Requirement of PML SUMO interacting motif for RNF4- or arsenic trioxide-induced degradation of nuclear PML isoforms.

PloS one - 1 Jan 2012

Maroui Mohamed Ali, Kheddache-Atmane Sabrina, El Asmi Faten, Dianoux Laurent, Aubry Muriel, Chelbi-Alix Mounira K

Abstract excerpt

PML, the organizer of nuclear bodies (NBs), is expressed in several isoforms designated PMLI to VII which differ in their C-terminal region due to alternative splicing of a single gene. This variability is important for the function of the different PML isoforms. PML NB formation requires the covalent linkage of SUMO to PML. Arsenic trioxide (As₂O₃) enhances PML SUMOylation leading to an increase in PML NB size...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promyelocytic Leukemia Protein

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Source

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Identifiers

PMID: 23028697
DOI: 10.1371/journal.pone.0044949
PMCID: PMC3445614

Genes

PML
RNF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Requirement of PML SUMO interacting motif for RNF4- or arsenic trioxide-induced degradation of nuclear PML isoforms.PMID 23028697Read ↗

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